How SeraSeal® Works
The initiation of the hemostatic sealing properties of SeraSeal® begins with the release of tissue thromboplastin from the creation of a wound. This triggering device causes a series of complex reactions to occur. Initially, the ions of platelet phospholipids and cations from amine groups in fibrinogen/fibrin monomers and tissue proteins, cross-link with the agar in SeraSeal®, creating an α-1,6-linked galactophospho and α-1,6-galactoamine forming an agar barrier over the wound. This barrier reduces blood from escaping through the opening of the wound, allowing the patient´s clotting cascade system to form a fibrin clot sooner.
There are two distinct pathways for fibrin clot formation: the extrinsic and intrinsic pathways. The vitamin K factors in SeraSeal® support both clotting pathways to form a fibrin clot in seconds instead of minutes. The fibrin clot adheres to the initial agar barrier, reinforcing the physical sealant.
SeraSeal® Clotting Cascade
SEALANT PROPERTIES
Platelets + galactopyranose complex sugar (agar) Polymerization thin transparent barrier.
Platelet Phospholipid ions and cations from amine groups in fibrinogen/fibrin monomers and tissue proteins adhere to the polymerized complex sugar, forming a barrier over the wound.
| SeraSeal® | Fibrin Glues
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| Composition
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SeraSeal® is a primary one component system containing agar, bovine proteins, stabilizers, an antiseptic agent. SeraSeal is fibrinogen and collagen free.
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Fibrin Glues are an adjunct two component system containing human fibrinogen or bovine collagen in one chamber, and thrombin or a polyol in another chamber.
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| Action
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SeraSeal® creates an agar physical barrier over the wound and reinforced with a fibrin clot.
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Fibrin Glues utilizes the cross-linking of two components to form a patch over the bleeding site; thereby, impeding blood flow and passively allowing the patient’s blood to clot to seal the wound.
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| Clotting times
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SeraSeal® achieves hemostasis in 2-3 seconds for most bleeds, and < 10 seconds for large arterial bleeds.
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Fibrin Glues typically clot venous bleeds in 1-3 minutes, and 5-10 minutes for small arterial hemorrhages.
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| Capacity
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SeraSeal® effective in a wide range of coagulopathies without significantly increasing clotting times.
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Fibrin Glues require preparation before use and cannot be used in all surgical procedures.
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| Versatility
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SeraSeal® can arrest any type of hemorrhage in any part of the body. No preparation, no mixing, ready to use.
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Fibrin Glues are used on venous bleeds, and only small arterial blood vessels.
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| Application
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Multiple delivery systems for different levels of hemorrhage. Can be used in emergency and trauma procedures. | Fibrin Glues limited to mild to moderate forms of hemorrhage.
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